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Tocris/SNAP 94847 hydrochloride/3347/50/50 mg

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货号: 3347/50

品牌: Tocris

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Description: Potent and selective MCH₁ antagonist

Chemical Name: N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent melanin-concentrating hormone receptor 1 (MCH₁) antagonist (K_i = 2.2 nM, K_D = 530 pM) that displays > 80-fold and > 500-fold selectivity over α_1A and D₂ receptors respectively. Increases neurogenesis in the dentate gyrus and decreases food-reinforced operant responding in vivo. Exhibits anxiolytic activity and is orally active.

Compound Libraries

SNAP 94847 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	515.03
Formula	C₂₉H₃₂F₂N₂O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	487051-12-7
PubChem ID	56972235
InChI Key	DEDUDFNRQKUBRH-UHFFFAOYSA-N
Smiles	CC1=CC=C(NC(C(C)C)=O)C=C1C(CC4)CCN4CC(C=C3)=CC=C3OC2=CC(F)=C(F)C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.5	100
	ethanol	51.5	100

Preparing Stock Solutions

The following data is based on the product molecular weight 515.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.71 mL	19.42 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2007) Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key features of HTS hits. J.Med.Chem. 50 3883 PMID: 17668922

David et al (2007) Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of J.Pharmacol.Exp.Ther. 321 237 PMID: 17237257

Nair et al (2009) Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats. Psychopharmacology 205 129 PMID: 19340414

Keywords: SNAP 94847 hydrochloride, supplier, Potent, selective, MCH1, antagonists, Melanin-concentrating, Hormone, Receptors, SNAP94847, hydrochloride, MCHR1, MCH1R, Melanin-concentrating, Hormone, Receptors, Melanin-concentrating, Hormone, Receptors, Tocris Bioscience

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