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Tocris/ATC 0175 hydrochloride/3346/10/10 mg
  • Tocris/ATC 0175 hydrochloride/3346/10/10 mg

Tocris/ATC 0175 hydrochloride/3346/10/10 mg

价格: ¥2460.00 市场价: 4100.00
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货号: 3346
品牌: Tocris
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    • Description:MCH1antagoNIST;also5-HT2Bantagonistand5-HT1Apartialagonist
      ChemicalName:N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloride
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      Potent,selectiveandorallyactivemelanin-concentratinghormonereceptor1(MCH1)antagonist(IC50valuesare13.5and>10000nMforMCH1andMCH2receptorsrespectively).Exhibitsanxiolyticandantidepressantactivityinrodents.Alsodisplaysaffinityfor5-HT2Band5-HT1Areceptors(IC50valuesare9.66and16.9nMrespectively).

      TechnicalData

      M.Wt461.94
      FormulaC23H25F2N5O.HCl
      StorageStoreat+4°C
      Purity≥98%(HPLC)
      CASNumber510733-97-8
      PubChemID9934032
      InChIKeyHUUPKFUYSQNNLO-UHFFFAOYSA-N
      SmilesO=C(C4=CC(F)=C(F)C=C4)N[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO4.6210
      ethanol11.5525

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight461.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM2.16mL10.82mL21.65mL
      5mM0.43mL2.16mL4.33mL
      10mM0.22mL1.08mL2.16mL
      50mM0.04mL0.22mL0.43mL