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Tocris/CART (62-76) (rat, human)/3339/1/1 mg

价格: ¥2388.00 市场价: 3980.00

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货号: 3339/1

品牌: Tocris

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Description: Neuromodulating neuropeptide fragment; inhibits food intake in vivo

Alternative Names: Cocaine and amphetamine-regulated transcript (62-76) (rat, human)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.

Technical Data

M. Wt	1570.77
Formula	C₆₄H₉₉N₁₇O₂₃S₃
Sequence	YGQVPMCDAGEQCAV
Storage	Store at -20°C
CAS Number	210978-19-1
PubChem ID	90488836
InChI Key	PSFNEVMDUKVDPJ-XJHNVALUSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 1 mg/ml in 20% acetonitrile / water

Solubility

Soluble to 1 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1570.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.64 mL	3.18 mL	6.37 mL
5 mM	0.13 mL	0.64 mL	1.27 mL
10 mM	0.06 mL	0.32 mL	0.64 mL
50 mM	0.01 mL	0.06 mL	0.13 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Volkoff and Peter (2000) Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding. Brain Res. 887 125 PMID: 11134597

Vaarmann and Kask (2001) Cocaine and amphetamine-regulated transcript peptide (CART62-76)-induced changes in regional monoamine levels in rat brain. Neuropeptides 35 292 PMID: 12030814

Colombo et al (2003) Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on release of insulin from isolated rat islets. Pancreas 27 161 PMID: 12883265

Keywords: CART (62-76) (rat, human), supplier, Neuromodulating, neuropeptide, fragment, inhibits, inhibitors, food, intake, vivo, Peptide, Receptor, Receptors, Cocaine, amphetamine-regulated, transcript, CART, peptide, amphetamine, neuropeptides, cart62-76, Cocaine, and, amphetamine-regulated, transcript, (62-76), (rat,, human), Other, Peptide, Receptors, Other, Peptide, Receptors, Tocris Bioscience

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