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Tocris/AZ 10606120 dihydrochloride/3323/10/10 mg

价格: ¥2028.00 市场价: 3380.00

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货号: 3323/10

品牌: Tocris

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Description: Potent P2X₇ receptor antagonist

Chemical Name: N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent P2X₇ receptor antagonist (K_D values are 1.4 and 19 nM at human and rat P2X₇ receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Compound Libraries

AZ 10606120 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	495.48
Formula	C₂₅H₃₄N₄O₂.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	607378-18-7
PubChem ID	56972227
InChI Key	BVFONFUUWORSPO-UHFFFAOYSA-N
Smiles	O=C(NC4=C(C=CC(NCCNCCO)=N5)C5=CC=C4)CC1(C3)CC2CC(CC3C2)C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.55	100
	water	12.39	25

Preparing Stock Solutions

The following data is based on the product molecular weight 495.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.09 mL	20.18 mL
5 mM	0.4 mL	2.02 mL	4.04 mL
10 mM	0.2 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Michel et al (2007) Direct labelling of the human P2X₇ receptor and identification of positive and negative cooperativity of binding. Br.J.Pharmacol. 151 103 PMID: 17339830

Michel and Fonfria (2007) Agonist potency at P2X₇ receptors is modulated by structurally diverse lipids. Br.J.Pharmacol. 152 523 PMID: 17700717

Michel et al (2008) Negative and positive allosteric modulators of the P2X₇ receptor. Br.J.Pharmacol. 153 737 PMID: 18071294

Adinolfi et al (2012) Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res. 72 2957 PMID: 22505653

Keywords: AZ 10606120 dihydrochloride, supplier, Potent, P2X7, receptor, antagonists, Receptors, Purinergic, purinoceptors, AZ10606120, dihydrochloride, AstraZeneca, P2X, Receptors, P2X, Receptors, Tocris Bioscience

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