Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Sodium salt of VU 0155041 (Cat. No. 3248).
Technical Data
|
M. Wt
|
338.16 |
|
Formula
|
C14H14Cl2NNaO3 |
|
Storage
|
Desiccate at RT |
|
Purity
|
≥98% (HPLC) |
|
CAS Number
|
1259372-69-4 |
|
PubChem ID
|
90488828 |
|
InChI Key
|
ISTRFEKLZQLUBR-ZQMRVLLOSA-L |
|
Smiles
|
[Na+].[Na+].[O-]C(=O)[C@H]1CCCC[C@H]1C(=O)NC1=CC(Cl)=CC(Cl)=C1.[O-]C(=O)[C@@H]1CCCC[C@@H]1C(=O)NC1=CC(Cl)=CC(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 338.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
2.96 mL |
14.79 mL |
29.57 mL |
| 5 mM |
0.59 mL |
2.96 mL |
5.91 mL |
| 10 mM |
0.3 mL |
1.48 mL |
2.96 mL |
| 50 mM |
0.06 mL |
0.3 mL |
0.59 mL |
Reconstitution Calculator
References
References are publications that support the products' biological activity.
Niswender
et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol.Pharmacol. 74 1345 PMID: 18664603
Keywords: VU 0155041 sodium salt, supplier, Potent, positive, allosteric, mGlu4, mGluR4, agonists, Sodium, salt, mGlur, Group, III, Receptors, Glutamate, Metabotropic, VU0155041, sodium, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience
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