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Tocris/Zileuton/3308/50/50 mg

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货号: 3308/50

品牌: Tocris

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Description: 5-LOX inhibitor; orally bioavailable

Alternative Names: ICI D2138

Chemical Name: N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB₄ synthesis (IC₅₀ values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC₅₀ = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (K_i = 66 - 98 μM).

Compound Libraries

Zileuton is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	236.29
Formula	C₁₁H₁₂N₂O₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	111406-87-2
PubChem ID	60490
InChI Key	MWLSOWXNZPKENC-UHFFFAOYSA-N
Smiles	CC(N(O)C(N)=O)C2=CC1=CC=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.63	100

Preparing Stock Solutions

The following data is based on the product molecular weight 236.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.16 mL	42.32 mL
5 mM	0.85 mL	4.23 mL	8.46 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

McMillan et al (1992) Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br.J.Pharmacol. 107 1042 PMID: 1334748

Malo et al (1994) The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. Pulm.Pharmacol. 7 73 PMID: 8081074

Lu et al (2003) Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab.Dispos. 31 1352 PMID: 14570767

Keywords: Zileuton, supplier, Orally, active, 5-LOX, inhibitors, inhibits, Lipoxygenase, Oxygenases, Oxidases, ICID2138, 5-LOX, ferroptosis, inhibitors, inhibits, ICI, D2138, Lipoxygenase, Ferroptosis, Lipoxygenase, Tocris Bioscience

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