BIOLOGicalActivityTechnicalDataDatasheetsReferences
BiologicalActivity
Neuronalnicotinicreceptorantagonistthatdisplaysselectivityfortheα9α10subtype(IC50valuesare19,140,980,4200and7300nMforα9α10,α6/α3β2β3,α6/α3β4,α3β4andα3β2subtypesrespectively).Alleviatesneuropathicpaininthreeratmodelsofhumanneuropathicpainandacceleratesfunctionalrecoveryofinjuredneurons.
LicensingInformation
SoldunderlicensefromDrBruceLivett
TechnicalData
| M.Wt | 1806.98 |
| Formula | C71H103N23O25S4 |
| Sequence | GCCSDPRCNYDHPEIC (Modifications:Cys-16-C-terminalamide,Disulfidebridgebetween2-8,3-16) |
| Storage | Storeat-20°C |
| CASNumber | 740980-24-9 |
| PubChemID | 76321093 |
| InChIKey | KJQOYUHYAZGPIZ-PIJHVLQJSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(N)=O)NC2=O)[C@@H](C)CC)C(N)=O)NC1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1806.98.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 0.55mL | 2.77mL | 5.53mL |
| 5mM | 0.11mL | 0.55mL | 1.11mL |
| 10mM | 0.06mL | 0.28mL | 0.55mL |
| 50mM | 0.01mL | 0.06mL | 0.11mL |
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