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Tocris/Talopram hydrochloride/3145/10/10 mg

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货号: 3145/10

品牌: Tocris

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Description: Potent, selective inhibitor of noradrenalin transporters

Alternative Names: Lu 3-010

Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenyl-1-isobenzofuranpropanamine hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, selective inhibitor of the noradrenalin transporter (NET) (IC₅₀ = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).

Compound Libraries

Talopram hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	331.88
Formula	C₂₀H₂₅NO.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	7013-41-4
PubChem ID	71176
InChI Key	JZXJIRQPHHWYGC-UHFFFAOYSA-N
Smiles	CC2(C)OC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.19	100
	ethanol	33.19	100
	water	16.59	50

Preparing Stock Solutions

The following data is based on the product molecular weight 331.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.13 mL
5 mM	0.6 mL	3.01 mL	6.03 mL
10 mM	0.3 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Bogeso et al (1985) 3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. J.Med.Chem. 28 1817 PMID: 2999402

Eildal et al (2008) From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J.Med.Chem. 51 3045 PMID: 18429609

Schou et al (2006) Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1 PMID:

Keywords: Talopram hydrochloride, supplier, potent, selective, inhibitors, inhibits, noradrenalin, epinephrine, adrenergics, transporters, net, Lu3-010, noradrenaline, Lu, 3-010, Adrenergic, Transporters, Adrenergic, Transporters, Tocris Bioscience

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