BIOLOGicalActivityTechnicalDataDatasheetsReferences
BiologicalActivity
Potent,non-competitiveNMDAreceptorantagonist(IC50=93nM)thathasbeensuggestedtohaveNR2subunitselectivity.InhibitsinwardcurrentsevokedbyNMDAincentralnervoussystemneurons(IC50=350nM)andexhibitsbroadanticonvulsantandantiparkinsonianactivityinvivoatdosesdevoidofbehavioraltoxicity.
LicensingInformation
SoldunderlicensefromUniversityofUtah
TechnicalData
| M.Wt | 3098.4 |
| Formula | C127H201N35O49S3 |
| Sequence | GEXXVAKMAAXLARXNIAKGCKVNCYP (Modifications:X=Gla,Disulfidebridgebetween21-25) |
| Storage | Storeat-20°C |
| CASNumber | 202925-60-8 |
| PubChemID | 90488802 |
| InChIKey | MJQQZSPLVNQFRB-HHXUSTKESA-N |
| Smiles | [H]NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight3098.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 0.32mL | 1.61mL | 3.23mL |
| 5mM | 0.06mL | 0.32mL | 0.65mL |
| 10mM | 0.03mL | 0.16mL | 0.32mL |
| 50mM | 0.01mL | 0.03mL | 0.06mL |
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