BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Nicotinicreceptorantagonistthatdisplaysselectivityforhomomericα7andα9receptors(IC50valuesare220and1800nMrespectively).Displaysnoeffectonα2β2,α3β2,α4β2,α2β4,α3β3andα4β4subunitcombinations.
LicensingInformation
SoldunderlicensefromUniversityofUtah
TechnicalData
| M.Wt | 1351.6 |
| Formula | C52H78N20O15S4 |
| Sequence | GCCSDPRCAWRC (Modifications:Cys-12=C-terminalamide,Disulfidebridgebetween2-8,3-12) |
| Storage | Storeat-20°C |
| CASNumber | 156467-85-5 |
| PubChemID | 76324742 |
| InChIKey | AIKMSOHWSGWCNX-VAYQAVKTSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlin20%acetonitrile/water |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1351.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 0.74mL | 3.7mL | 7.4mL |
| 5mM | 0.15mL | 0.74mL | 1.48mL |
| 10mM | 0.07mL | 0.37mL | 0.74mL |
| 50mM | 0.01mL | 0.07mL | 0.15mL |
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