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Tocris/Thioridazine hydrochloride/3070/50/50 mg

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货号: 3070/50

品牌: Tocris

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Description: Dopamine receptor antagonist; antipsychotic

Chemical Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G₁ cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.

Compound Libraries

Thioridazine hydrochloride is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	407.04
Formula	C₂₁H₂₆N₂S₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	130-61-0
PubChem ID	66062
InChI Key	NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Smiles	CN(CCCC4)C4CCN2C3=C(C=CC(SC)=C3)SC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.7	100
	ethanol	20.35	50
	water	30.53	75

Preparing Stock Solutions

The following data is based on the product molecular weight 407.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.28 mL	24.57 mL
5 mM	0.49 mL	2.46 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Merck Index 13 9435 PMID:

Sachlos et al (2012) Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print PMID: 22632761

Kang et al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print PMID: 22460505

Keywords: Thioridazine hydrochloride, supplier, Dopamine, receptor, antagonists, antipsychotic, D2-like, Non-Selective, Receptors, dopaminergic, anticancer, Non-selective, Dopamine, Cancer, Stem, Cells, Cancer, Stem, Cell, Differentiation, Non-selective, Dopamine, Tocris Bioscience

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