Interleukin-13 (IL-13) is an important cytokine secreted from Th2cells. The functions attributed to IL-13 overlap significantlywith those of IL-4 (induces IgE secretion from B cells andinhibits expression of inflammatory cytokines such as IL-1β,TNF-α, IL-8 and IL-6), but differs from IL-4 in that IL-13 seemsto link inflammatory response of immune cells to thepathophysiological changes in the surrounding non-immune cells.The receptor subunits of IL-13 consist of IL-4Rα, IL-13Rα1 andIL-13Rα2. Human and mouse IL-13 are cross-reactive.Recombinantmouse IL-13 is a non-glycosylated protein containing 110 aminoacids and having a molecular mass of 12.3 kDa.
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