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Tocris/PI 103 hydrochloride/2930/1/1 mg

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货号: 2930/1

品牌: Tocris

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Description: Inhibitor of PI 3-kinase, mTOR and DNA-PK

Chemical Name: 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC₅₀ values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.

Compound Libraries

PI 103 hydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	384.82
Formula	C₁₉H₁₆N₄O₃.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	371935-79-4
PubChem ID	16739368
InChI Key	XSQMYBFFYPTMFE-UHFFFAOYSA-N
Smiles	OC1=CC(C(N=C4N5CCOCC5)=NC3=C4OC2=NC=CC=C23)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.7	20

Preparing Stock Solutions

The following data is based on the product molecular weight 384.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.6 mL	12.99 mL	25.99 mL
5 mM	0.52 mL	2.6 mL	5.2 mL
10 mM	0.26 mL	1.3 mL	2.6 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Fan et al (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 9 341 PMID: 16697955

Knight et al (2006) A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 125 733 PMID: 16647110

Raynaud et al (2007) Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase. Cancer Res. 67 5840 PMID: 17575152

Fan et al (2010) Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci.Signal. 3 ra81 PMID: 21062993

Keywords: PI 103 hydrochloride, supplier, inhibitors, inhibits, DNA-PK, mTOR, PI, 3-kinase, DNA-Dependent, Protein, Kinases, Mammalian, Target, Rapamycin, PI103, hydrochloride, PI, 3-Kinase, mTOR, DNA-dependent, Protein, Kinase, Inositol, Lipids, Checkpoint, Control, Kinases, Autophagy, PI, 3-Kinase, Tocris Bioscience

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