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Tocris/Flupirtine maleate/2867/50/50 mg

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货号: 2867/50

品牌: Tocris

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Description: K_V7 channel activator

Alternative Names: D 9998

Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Non-opioid analgesic with muscle relaxant properties. Activates K_V7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABA_A receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Compound Libraries

Flupirtine maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	420.4
Formula	C₁₅H₁₇FN₄O₂.C₄H₄O₄
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	75507-68-5
PubChem ID	53276
InChI Key	JUUFBMODXQKSTD-UHFFFAOYSA-N
Smiles	OC(=O)C=C/C(O)=O.NC1=C(NC(OCC)=O)C=CC(NCC2=CC=C(F)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.04	100
	ethanol	4.2	10

Preparing Stock Solutions

The following data is based on the product molecular weight 420.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.89 mL	23.79 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Osborne et al (1998) Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen.Pharmacol. 30 255 PMID: 9510072

Azad et al (2004) The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice. Neurosci.Lett. 370 186 PMID: 15488320

Yeung et al (2007) Molecular expression and pharmacological identification of a role for K_v7 channels in murine vascular reactivity. Br.J.Pharmacol. 151 758 PMID: 17519950

Klinger (2012) Concomitant facilitation of GABA_A receptors and K_V7 channels by the non-opioid analgesic flupirtine. Br.J.Pharmacol. 166 1631 PMID: 22188423

Keywords: Flupirtine maleate, supplier, K+, channel, activators, Indirect, NMDA, receptors, antagonists, Potassium, Channels, kv7, GABA, GABAA, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, D9998, D, 9998, Voltage-Gated, Potassium, Channels, NMDA, Receptors, GABAA, Receptors, Voltage-Gated, Potassium, Channels, Tocris Bioscience

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