Biological Activity
Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.
Technical Data
|
M. Wt
|
462.67 |
|
Formula
|
C30H42N2O2 |
|
Storage
|
Store at -20°C |
|
CAS Number
|
187947-37-1 |
|
PubChem ID
|
10027372 |
|
InChI Key
|
QJDNHGXNNRLIGA-DOFZRALJSA-N |
|
Smiles
|
O=C(NCCC1=CNC2=C1C=C(O)C=C2)CCCC=C/CC=C/C/C=CC/C=CCCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 462.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
2.16 mL |
10.81 mL |
21.61 mL |
| 5 mM |
0.43 mL |
2.16 mL |
4.32 mL |
| 10 mM |
0.22 mL |
1.08 mL |
2.16 mL |
| 50 mM |
0.04 mL |
0.22 mL |
0.43 mL |
Reconstitution Calculator
References
References are publications that support the products' biological activity.
Di Marzo
et al (2004) The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 3 771 PMID: 15340387
Maione
et al (2007) Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 150 766 PMID: 17279090
Bisogno
et al (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms. 248 515 PMID:
Keywords: Arachidonyl serotonin, supplier, Dual, FAAH, inhibitors, inhibits, TRPV1, antagonists, cannabinoids, Receptors, Vanillioid, VR1, Channels, Transient, Receptor, Potential, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, AA5HT, AA-5-HT, Other, Cannabinoids, TRPV, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, Tocris Bioscience
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