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Tocris/Valproic acid, sodium salt/2815/100/100 mg

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货号: 2815/100

品牌: Tocris

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Description: Histone deacetylase inhibitor

Alternative Names: VPA, Sodium Valproate

Chemical Name: Sodium 2-propylpentanoate

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Histone deacetylase inhibitor (IC₅₀ = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na⁺ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis.

Compound Libraries

Valproic acid, sodium salt is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	166.19
Formula	C₈H₁₅NaO₂
Storage	Desiccate at RT
CAS Number	1069-66-5
PubChem ID	16760703
InChI Key	AEQFSUDEHCCHBT-UHFFFAOYSA-M
Smiles	[Na+].CCCC(CCC)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	8.31	50
	water	16.62	100

Preparing Stock Solutions

The following data is based on the product molecular weight 166.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.02 mL	30.09 mL	60.17 mL
5 mM	1.2 mL	6.02 mL	12.03 mL
10 mM	0.6 mL	3.01 mL	6.02 mL
50 mM	0.12 mL	0.6 mL	1.2 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Phiel et al (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276 36734 PMID: 11473107

Kostrouchova et al (2007) Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 53 37 PMID: 17448293

Kim et al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 321 892 PMID: 17371805

Qing et al (2008) Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 205 2781 PMID: 18955571

Huangfu et al (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 26 1269 PMID: 18849973

Keywords: Valproic acid, sodium salt, supplier, Histone, deacetylases, inhibitors, inhibits, Increases, GABA, levels, anticonvulsant, HDAC, GABAA, GABAC, Receptors, GABAB, stem, cells, epigenetics, VPA, Sodium, Valproate, Histone, Deacetylases, Miscellaneous, GABA, GABAB, Receptors, Reprogramming, Autophagy, Voltage-gated, Sodium, Channels, Histone, Deacetylases, Tocris Bioscience

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