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Tocris/Zoniporide dihydrochloride/2727/50/50 mg

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货号: 2727/50

品牌: Tocris

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Description: Selective NHE1 inhibitor

Alternative Names: CP 597396

Chemical Name: [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (K_i values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent ²²Na⁺ uptake in vitro (IC₅₀ = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC₅₀ = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries

Zoniporide dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	393.27
Formula	C₁₇H₁₆N₆O.2HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	241799-10-0
PubChem ID	22267855
InChI Key	ARZNPJAGKWHEHT-UHFFFAOYSA-N
Smiles	O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.33	100
	water	3.93	10

Preparing Stock Solutions

The following data is based on the product molecular weight 393.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.71 mL	25.43 mL
5 mM	0.51 mL	2.54 mL	5.09 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Knight et al (2001) A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 297 254 PMID: 11259552

Marala et al (2002) Zoniporide: a potent and highly selective inhibitor of human Na⁺/H⁺ exchanger-1. Eur.J.Pharmacol. 451 37 PMID: 12223226

Clements-Jewery et al (2004) Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 142 57 PMID: 15037516

Keywords: Zoniporide dihydrochloride, supplier, Selective, NHE-1, inhibitors, inhibits, Ion, Pumps, Transporters, Sodium-hydrogen, exchanger, isoform-1, CP597396, CP, 597396, Na+/H+, Exchanger, Na+/H+, Exchanger, Tocris Bioscience

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