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Tocris/Sodium 4-Phenylbutyrate/2682/100/100 mg

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货号: 2682/100

品牌: Tocris

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Description: Histone deacetylase inhibitor

Alternative Names: 4-PB, Sodium phenylbutyrate

Chemical Name: 4-Phenylbutyric acid, sodium salt

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.

Compound Libraries

Sodium 4-Phenylbutyrate is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox, Tocriscreen Library of FDA-Approved Compounds and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	186.18
Formula	C₁₀H₁₁NaO₂
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	1716-12-7
PubChem ID	5258
InChI Key	VPZRWNZGLKXFOE-UHFFFAOYSA-M
Smiles	[Na+].[O-]C(=O)CCCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.65	25
	water	18.61	100

Preparing Stock Solutions

The following data is based on the product molecular weight 186.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.37 mL	26.86 mL	53.71 mL
5 mM	1.07 mL	5.37 mL	10.74 mL
10 mM	0.54 mL	2.69 mL	5.37 mL
50 mM	0.11 mL	0.54 mL	1.07 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Appelskog et al (2004) Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells. Int.J.Oncol. 24 1419 PMID: 15138583

Ammerpohl et al (2007) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br.J.Cancer 96 73 PMID: 17164759

Engelhard et al (1998) Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. J.Neuro-Oncol. 37 97 PMID:

Khan et al (2011) HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int.J.Mol.Med. 28 977 PMID: 21894430

Keywords: Sodium 4-Phenylbutyrate, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, 4-PB, Sodium, phenylbutyrate, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience

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