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Tocris/GW 9508/2649/10/10 mg

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货号: 2649/10

品牌: Tocris

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Description: Potent and selective FFA1 (GPR40) agonist

Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC₅₀ values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC₅₀ = 6.14).

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries

GW 9508 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	347.41
Formula	C₂₂H₂₁NO₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	885101-89-3
PubChem ID	11595431
InChI Key	DGENZVKCTGIDRZ-UHFFFAOYSA-N
Smiles	OC(=O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.74	100
	ethanol	34.74	100

Preparing Stock Solutions

The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.88 mL	14.39 mL	28.78 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
10 mM	0.29 mL	1.44 mL	2.88 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Garrido et al (2006) Synthesis and activity of small molecule GPR40 agonists. Bioorg.Med.Chem.Lett. 16 1840 PMID: 16439116

Briscoe et al (2006) Pharmacological regulation of insulin secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br.J.Pharmacol. 148 619 PMID: 16702987

Zhao and Chen (2008) Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J.Endocrinol. 198 533 PMID: 18550787

Keywords: GW 9508, supplier, Potent, selective, FFA1, GPR40, agonists, Receptors, Free, Fatty, Acid, GW9508, GlaxoSmithKline, GSK, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience

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