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Tocris/ST 91/2638/10/10 mg

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货号: 2638/10

品牌: Tocris

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Description: α₂ agonist, putative α_2C agonist

Chemical Name: N-(2,6-Diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

α₂-adrenoceptor agonist that does not cross the blood brain barrier. Displays ~ 120-fold selectivity for α₂ receptors over α₁ receptors and acts predominantly at non-α_2A-adrenoceptors which may be of the α_2C subtype. Antinociceptive; increases tail-flick latencies in Sasco and Harlan rats.

Compound Libraries

ST 91 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	253.77
Formula	C₁₃H₁₉N₃.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	4749-61-5
PubChem ID	20863
InChI Key	ZLRWFGBEDNTMEU-UHFFFAOYSA-N
Smiles	CCC2=C(C(CC)=CC=C2)/N=C1NCCN/1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.38	100
	ethanol	25.38	100
	water	25.38	100

Preparing Stock Solutions

The following data is based on the product molecular weight 253.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.94 mL	19.7 mL	39.41 mL
5 mM	0.79 mL	3.94 mL	7.88 mL
10 mM	0.39 mL	1.97 mL	3.94 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Takano and Yaksh (1992) Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J.Pharmacol.Exp.Ther. 261 764 PMID: 1349648

Celly et al (1999) Cardiopulmonary effects of the α₂-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. J.Pharmacol.Exp.Ther. 289 712 PMID: 10215644

Graham et al (2000) Synergistic interactions between two α₂-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain 85 135 PMID: 10692612

Keywords: ST 91, supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, putative, α2C-adrenoceptor, alpha2C-adrenoceptors, α2c-adrenergic, alpha2c-adrenergic, a2c-adrenoceptor, a2c-adrenergic, Receptors, ST, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience

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