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Tocris/Ryuvidine/2609/50/50 mg

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货号: 2609/50

品牌: Tocris

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Description: SETD8 inhibitor; also CDK4 inhibitor

Chemical Name: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC₅₀ = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC₅₀ = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.

Compound Libraries

Ryuvidine is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	284.33
Formula	C₁₅H₁₂N₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	265312-55-8
PubChem ID	481747
InChI Key	HFPLHASLIOXVGS-UHFFFAOYSA-N
Smiles	CC1=NC2=C(S1)C(=O)C=C(NC1=CC=C(C)C=C1)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	5.69	20
	ethanol	1.42	5

Preparing Stock Solutions

The following data is based on the product molecular weight 284.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.17 mL
5 mM	0.7 mL	3.52 mL	7.03 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ryu et al (2000) 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg.Med.Chem.Lett. 10 461 PMID: 10743948

Blum et al (2014) Small-molecule inhibitors of SETD8 with cellular activity. ASC.Chem.Biol. [Epub ahead of print] 9 2471 PMID: 25137013

Keywords: Ryuvidine, supplier, Cyclin-dependent, protein, kinase, 4, cdk4, inhibitors, SETD8, protein, lysine, methyltransferases, inhibits, SPS8I2, Cyclin-dependent, Kinase, Lysine, Methyltransferases, Lysine, Methyltransferases, Lysine, Methyltransferases, Tocris Bioscience

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