Chemical Name: (3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (Ki values are 447 and 1305 nM for D2 and D3 receptors respectively and > 1 μM for other targets). Exhibits high D2 receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
M. Wt
317.87
Formula
C15H23NO2S.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
CAS Number
156907-84-5
PubChem ID
9836644
InChI Key
LEMGVHZVBREXAD-PFEQFJNWSA-N
Smiles
CCCN(C2)CCC[C@@]2([H])C1=CC=CC(S(=O)(C)=O)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
31.79
100
water
31.79
100
Preparing Stock Solutions
The following data is based on the product molecular weight 317.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.15 mL
15.73 mL
31.46 mL
5 mM
0.63 mL
3.15 mL
6.29 mL
10 mM
0.31 mL
1.57 mL
3.15 mL
50 mM
0.06 mL
0.31 mL
0.63 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Nicholset al (2002) PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by dopamine agonists in a rat model for Parkinson's disease. Neuropharmacology 43 817 PMID: 12384167
Natesanet al (2006) The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low po J.Pharmacol.Exp.Ther. 318 810 PMID: 16648369
Runget al (2005) The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog.Neuro-Psychopharm.Biol.Psychiat. 29 833 PMID:
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