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Tocris/Tenidap/2580/50/50 mg

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货号: 2580/50

品牌: Tocris

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Description: NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of K_IR2.3

Alternative Names: CP 66248

Chemical Name: (Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

NSAID that preferentially inhibits COX-1 (IC₅₀ values are < 0.03, 1.2 and > 30 μM for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK_ir2.3 channel (EC₅₀ = 402 nM).

Compound Libraries

Tenidap is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	320.75
Formula	C₁₄H₉N₂O₃SCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	120210-48-2
PubChem ID	54683953
InChI Key	LXIKEPCNDFVJKC-QXMHVHEDSA-N
Smiles	O=C1N(C(N)=O)C2=CC=C(Cl)C=C2/C1=C(O)C3=CC=CS3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.07	100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.59 mL	31.18 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Moilanen et al (1988) CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. Eicosanoids 1 35 PMID: 2856170

Kirchner et al (1997) Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J.Pharmacol.Exp.Ther. 282 1094 PMID: 9262379

Liu et al (2002) Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K⁺ channel hKir2.3. Eur.J.Pharmacol. 435 153 PMID: 11821021

Keywords: Tenidap, supplier, NSAID, cyclooxygenase, COX-1, inhibitors, inhibits, KIR23, openers, Cyclooxygenase, Oxygenases, Oxidases, Potassium, KIR, Channels, KATP, Inward, Rectifier, K+, CP66248, CP, 66248, Cyclooxygenase, Inward, rectifier, Potassium, Channels, Cyclooxygenase, Tocris Bioscience

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