Chemical Name: 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.
Technical Data
M. Wt
250.09
Formula
C8H11NO3.HBr
Storage
Desiccate at -20°C
CAS Number
636-00-0
PubChem ID
176170
InChI Key
MLACDGUOKDOLGC-UHFFFAOYSA-N
Smiles
NCCC1=CC(O)=C(O)C=C1O.Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
20.56
100
water
20.56
100
Preparing Stock Solutions
The following data is based on the product molecular weight 250.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
4 mL
19.99 mL
39.99 mL
5 mM
0.8 mL
4 mL
8 mL
10 mM
0.4 mL
2 mL
4 mL
50 mM
0.08 mL
0.4 mL
0.8 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
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References
References are publications that support the products' biological activity.
Breese and Traylor
(1970) Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons. J.Pharmacol.Exp.Ther. 174 413 PMID: 5456173
Soto-Oteroet al (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J.Neurochem. 74 1605 PMID: 10737618
Fujitaet al (2006) Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 1113 10 PMID: 16945353