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Tocris/PKI 14-22 amide, myristoylated/2546/1/1 mg

价格: ¥1548.00 市场价: 2580.00

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货号: 2546/1

品牌: Tocris

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Description: Cell-permeable protein kinase A inhibitor

Alternative Names: Protein kinase inhibitor-(14-22)-amide, myristoylated

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (K_i = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data

M. Wt	1209.5
Formula	C₅₃H₁₀₀N₂₀O₁₂
Sequence	GRTGRRNAI (Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	201422-03-9
PubChem ID	71312213
InChI Key	GQPQKQWUUHDDIS-JDLJUXOTSA-N
Smiles	[H]N(CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 1 mg/ml in 30% acetonitrile / water

Solubility

Soluble to 1 mg/ml in 30% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1209.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.83 mL	4.13 mL	8.27 mL
5 mM	0.17 mL	0.83 mL	1.65 mL
10 mM	0.08 mL	0.41 mL	0.83 mL
50 mM	0.02 mL	0.08 mL	0.17 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802 PMID: 2722799

Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747 PMID: 10829013

Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197 PMID: 12947318

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