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Tocris/DPO-1/2533/50/50 mg

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货号: 2533/50

品牌: Tocris

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Description: Blocker of K_V1.5 channel and I_Kur current

Alternative Names: Diphenyl phosphine oxide-1

Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Blocker of I_Kur ultrarapid delayed rectifier potassium current and K_V1.5 channels (IC₅₀ = 0.31 μM for rK_V1.5). Displays selectivity for inhibition of I_Kur over I_to (8-fold), I_K1, I_Kr and I_Ks (20-fold) in native myocytes and selectivity for rat recombinant K_V1.5 over K_V3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Technical Data

M. Wt	340.44
Formula	C₂₂H₂₉OP
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	43077-30-1
PubChem ID	21678144
InChI Key	BPCNGVCAHAIZEE-COPCDDAFSA-N
Smiles	C[C@@H]1CC[C@@H]([C@@H](C)C)[C@@H]([P@@](C2=CC=CC=C2)(C3=CC=CC=C3)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	34.04	100

Preparing Stock Solutions

The following data is based on the product molecular weight 340.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.69 mL	29.37 mL
5 mM	0.59 mL	2.94 mL	5.87 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Stump et al (2005) In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide I_Kur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J.Pharmacol.Exp.Ther. 315 1362 PMID: 16157659

Regan et al (2006) In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide I_Kur blocker, (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate. J.Pharmacol.Exp.Ther. 316 727 PMID: 16243963

Lagrutta et al (2006) Novel, potent inhibitors of human Kv1.5 K⁺ channels and ultrarapid activating delayed rectifier potassium current. J.Pharmacol.Exp.Ther. 317 1054 PMID: 16522807

Keywords: DPO-1, supplier, blockers, KV15, channel, IKur, current, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Diphenylphosphine, oxide1, Diphenyl, phosphine, oxide-1, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience

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