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Tocris/TFB-TBOA/2532/10/10 mg

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货号: 2532/10

品牌: Tocris

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Description: High affinity EAAT1 and EAAT2 blocker

Chemical Name: (3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC₅₀ values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively). Has no effect on EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. Attenuates glutamate-stimulated intracellular Na⁺ elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo.

Licensing Information

Sold for research purposes under license from Suntory Ltd.

Technical Data

M. Wt	426.35
Formula	C₁₉H₁₇F₃N₂O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	480439-73-4
PubChem ID	52941382
InChI Key	LPWONNPEPDHEAI-GJZGRUSLSA-N
Smiles	OC([C@@H](N)[C@H](OCC1=CC=CC(NC(C2=CC=C(C(F)(F)F)C=C2)=O)=C1)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.63	100

Preparing Stock Solutions

The following data is based on the product molecular weight 426.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.73 mL	23.45 mL
5 mM	0.47 mL	2.35 mL	4.69 mL
10 mM	0.23 mL	1.17 mL	2.35 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Tsukada et al (2005) Effects of a novel glutamate transporter blocker, (2S, 3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate (TFB-TBOA), on activities of hippocampal neurons. Neuropharmacology 48 479 PMID: 15755476

Shimamoto and Shigeri (2006) Elucidation of glutamate transporter functions using selective inhibitors. CNS Agents Med.Chem. 6 59 PMID:

Magi et al (2012) Physical and functional interaction of NCX1 and EAAC1 transporters leading to glutamate-enhanced ATP production in brain mitochondria. PLoS One 7 e34015 PMID: 22479505

Bozzo and Chatton (2010) Inhibitory effects of (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate. Brain Res. 1316 PMID: 20026319

Keywords: TFB-TBOA, supplier, High, affinity, EAAT1, EAAT2, blockers, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience

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