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Tocris/Talniflumate/2510/50/50 mg

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货号: 2510/50

品牌: Tocris

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Description: CaCC blocker and Cl-/HCO3- exchange inhibitor

Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl^-/HCO₃^- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Compound Libraries

Talniflumate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	414.34
Formula	C₂₁H₁₃F₃N₂O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	66898-62-2
PubChem ID	48229
InChI Key	ANMLJLFWUCQGKZ-UHFFFAOYSA-N
Smiles	FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.36	25

Preparing Stock Solutions

The following data is based on the product molecular weight 414.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.07 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Walker et al (2006) Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome. J.Pharmacol.Exp.Ther. 317 275 PMID: 16354791

Sanchez et al (1982) Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats. J.Appl.Toxicol. 2 42 PMID:

Knight (2004) Talniflumate (Genaera). Curr.Opin.Invest.Drugs 5 557 PMID:

Keywords: Talniflumate, supplier, Cyclooxygenase, inhibitors, inhibits, chloride, channels, blockers, Chloride, hCLCA1/mCLCA3, COX, Oxygenases, Oxidases, Cl-/HCO3-, exchangers, CaCC, calcium-activated, Cyclooxygenase, Ca2+-Activated, Chloride, Channels, Ca2+-Activated, Chloride, Channels, Tocris Bioscience

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