Description:Monovalentcationionophore
AlternativeNames:AmmoniumIonophoreI
ChemicalName:(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
Purity:≥93%
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
MonovalentcationionophorethatdisplaysselectivityforK+andNH4+(K+=NH4+>Na+>Mg2+>Li+>>Ca2+fornonactin-EVAsensor).Inducescationtransportacrossartificialmembranes.AlsoinhibitsP-glycoprotein-mediatedeffluxofchemotherapeuticagentsinmultiple-drugresistantcancercells.Antibiotic.
TechnicalData
| M.Wt | 736.94 |
| Formula | C40H64O12 |
| Storage | Desiccateat-20°C |
| Purity | ≥93% |
| CASNumber | 6833-84-7 |
| PubChemID | 72519 |
| InChIKey | RMIXHJPMNBXMBU-QIIXEHPYSA-N |
| Smiles | [H][C@]3(CC[C@@](C[C@@H](C)OC([C@H](C)[C@@]4([H])CC[C@](C[C@H](C)OC([C@H]5C)=O)([H])O4)=O)([H])O3)[C@H](C)C(O[C@@H](C)C[C@@]1([H])O[C@]([C@@H](C)C(O[C@H](C)C[C@]2([H])O[C@@]5([H])CC2)=O)([H])CC1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| ethanol | 7.37 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight736.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.36mL | 6.78mL | 13.57mL |
| 5mM | 0.27mL | 1.36mL | 2.71mL |
| 10mM | 0.14mL | 0.68mL | 1.36mL |
| 50mM | 0.03mL | 0.14mL | 0.27mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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