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Tocris/Melperone hydrochloride/2495/50/50 mg

价格: ¥4260.00 市场价: 7100.00

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货号: 2495/50

品牌: Tocris

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Description: 5-HT_2A/D₂ receptor antagonist; neuroleptic

Chemical Name: 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Atypical neuroleptic; 5-HT_2A/D₂ receptor antagonist (K_i values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α₁ and α₂ receptors (K_i values are 180 and 150 nM respectively).

Compound Libraries

Melperone hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	299.81
Formula	C₁₆H₂₂FNO.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1622-79-3
PubChem ID	15386
InChI Key	MQHYXXIJLKFQGY-UHFFFAOYSA-N
Smiles	Cl.CC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.98	100
	ethanol	29.98	100
	water	29.98	100

Preparing Stock Solutions

The following data is based on the product molecular weight 299.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.68 mL	33.35 mL
5 mM	0.67 mL	3.34 mL	6.67 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Seeman et al (1997) Atypical neuroleptics have low affinity for dopamine D₂ receptors or are selective for D₄ receptors. Neuropsychopharmacology. 16 93 PMID: 9015795

Ichikawa et al (2002) Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT_1A receptor agonism. Brain Res. 956 349 PMID: 12445705

Uhr et al (2005) P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. J.Psychopharmacol. 18 509 PMID:

Keywords: Melperone hydrochloride, supplier, 5-HT2A/D2, receptor, antagonists, neuroleptic, Serotonin, Receptors, Dopamine, D2, dopaminergic, 5-HT2A, Receptors, D2, Receptors, 5-HT2A, Receptors, Tocris Bioscience

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