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Tocris/Lazabemide hydrochloride/2460/50/50 mg

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货号: 2460/50

品牌: Tocris

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Description: Selective MAO-B inhibitor

Alternative Names: Ro 19-6327

Chemical Name: N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀ values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC₅₀ values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).

Compound Libraries

Lazabemide hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	236.1
Formula	C₈H₁₀ClN₃O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	103878-83-7
PubChem ID	163727
InChI Key	JMFKTFLARGGXCC-UHFFFAOYSA-N
Smiles	Cl.NCCNC(=O)C1=NC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.61	100
	water	23.61	100

Preparing Stock Solutions

The following data is based on the product molecular weight 236.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.24 mL	21.18 mL	42.35 mL
5 mM	0.85 mL	4.24 mL	8.47 mL
10 mM	0.42 mL	2.12 mL	4.24 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Saura et al (1992) Quantitative enzyme radioautography with ³H-Ro 41-1049 and ³H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J.Neurosci. 12 1977 PMID: 1578281

Bondiolotti et al (1995) In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem.Pharmacol. 50 97 PMID: 7605351

Guimaraes and Soares-da-Silva (1998) The activity of MAO A and B in rat renal cells and tubules. Life Sci. 62 727 PMID: 9489509

Keywords: Lazabemide hydrochloride, supplier, Selective, MAO-B, inhibitors, inhibits, Monoamine, Oxygenases, Oxidases, Ro196327, Ro, 19-6327, Monoamine, Oxidase, Adrenergic, Related, Compounds, Dopaminergic-Related, 5-HT-Related, 5-HT3, Receptors, Monoamine, Oxidase, Tocris Bioscience

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