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Tocris/BIBX 1382 dihydrochloride/2416/1/1 mg
  • Tocris/BIBX 1382 dihydrochloride/2416/1/1 mg

Tocris/BIBX 1382 dihydrochloride/2416/1/1 mg

价格: ¥1260.00 市场价: 2100.00

货号: 2416/1
品牌: Tocris
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    • Description:HighlyselectiveEGFR-kinaseinhibitor
      ChemicalName:N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride
      Purity:≥97%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      Potent,selectiveinhibitorofepidermalgrowthfactorreceptor(EGFR)tyrosinekinase(IC50=3nM).Displays>1000-foldlowerpotencyagainstErbB2(IC50=3.4μM)andarangeofotherrelatedtyrosinekinases(IC50>10μM).OraladmiNISTrationinhibitsgrowthofestablishedhumanxenograftsinathymicmice.

      CompoundLibraries

      BIBX1382dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

      TechnicalData

      M.Wt460.77
      FormulaC18H19ClFN7.2HCl
      StorageDesiccateat+4°C
      Purity≥97%(HPLC)
      CASNumber1216920-18-1
      PubChemID46861540
      InChIKeyRFXGEKWBTCMDAW-UHFFFAOYSA-N
      SmilesCl.Cl.CN1CCC(CC1)NC1=NC=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=N1

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO19.3950
      water19.3950

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight460.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM2.17mL10.85mL21.7mL
      5mM0.43mL2.17mL4.34mL
      10mM0.22mL1.09mL2.17mL
      50mM0.04mL0.22mL0.43mL

      ProductDatasheets

      CertificateofAnalysis/ProductDatasheet
      SafetyDatasheet

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