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Tocris/Ambroxol hydrochloride/2404/50/50 mg

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货号: 2404/50

品牌: Tocris

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Description: Na⁺ channel blocker

Chemical Name: trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC₅₀ values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.

Compound Libraries

Ambroxol hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	414.57
Formula	C₁₃H₁₈Br₂N₂O.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	23828-92-4
PubChem ID	108013
InChI Key	QNVKOSLOVOTXKF-UHFFFAOYSA-N
Smiles	NC1=C(Br)C=C(Br)C=C1CN[C@H]2CC[C@H](O)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.72	50

Preparing Stock Solutions

The following data is based on the product molecular weight 414.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.06 mL	24.12 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Gillissen et al (1997) Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 175 235 PMID: 9195551

Gibbs et al (1999) Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm.Res. 48 86 PMID: 10202994

Weiser and Wilson (2002) Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na⁺ channels by the secretolytic ambroxol. Mol.Pharmacol. 62 433 PMID: 12181417

Keywords: Ambroxol hydrochloride, supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience

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