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Tocris/DMP 543/2330/10/10 mg

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货号: 2330/10

品牌: Tocris

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Description: Potent, orally active ACh release enhancer

Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Acetylcholine release stimulator. Potently enhances K⁺-stimulated [³H]-ACh release from rat hippocampal slices (EC₅₀ = 700 nM), and increases release of dopamine and glutamate (EC₅₀ values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo. Also K⁺ channel blocker.

Compound Libraries

DMP 543 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	412.44
Formula	C₂₆H₁₈F₂N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	160588-45-4
PubChem ID	9887884
InChI Key	MUJBUUDUXGDXLW-UHFFFAOYSA-N
Smiles	FC1=CC(CC2(CC3=CC(F)=NC=C3)C3=CC=CC=C3C(=O)C3=C2C=CC=C3)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.24	100
	ethanol	20.62	50

Preparing Stock Solutions

The following data is based on the product molecular weight 412.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.12 mL	24.25 mL
5 mM	0.48 mL	2.42 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724 PMID: 9580619

Earl et al (1998) 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 41 4615 PMID: 9804701

Keywords: DMP 543, supplier, K+, channels, blockers, potent, ACh, release, enhancer, Potent, orally, active, Potassium, Channels, Non-Selective, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, DMP543, Other, Acetylcholine, Non-selective, Muscarinics, Voltage-Gated, Potassium, Channels, Other, Acetylcholine, Tocris Bioscience

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