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Tocris/Sanguinarine chloride/2302/50/50 mg

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货号: 2302/50

品牌: Tocris

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Description: Inhibitor of protein phosphatase 2C (PP2C)

Chemical Name: 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride

Purity: ≥97% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC₅₀ = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G₁ phase; inhibits cell growth in human prostate carcinoma cells.

Technical Data

M. Wt	367.78
Formula	C₂₀H₁₄ClNO₄
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	5578-73-4
PubChem ID	68635
InChI Key	GIZKAXHWLRYMLE-UHFFFAOYSA-M
Smiles	C[N+]1=CC4=C(C=CC5=C4OCO5)C3=C1C2=CC(OCO6)=C6C=C2C=C3.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.68	10
	ethanol	1.84	5

Preparing Stock Solutions

The following data is based on the product molecular weight 367.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.6 mL	27.19 mL
5 mM	0.54 mL	2.72 mL	5.44 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Vogt et al (2005) The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem. 280 19078 PMID: 15753082

Aburai et al (2010) Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem. 74 548 PMID: 20208361

Adhami et al (2004) Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther. 3 934 PMID:

Keywords: Sanguinarine chloride, supplier, proapoptotic, anti-inflammatory, antioxidant, MKP-1, mitogen-activated, protein, kinase, phosphatase, inhibitors, blocks, cell, cycle, inhibits, protein, phosphase, 2C, PP2C, Protein, Ser/Thr, Phosphatases, Antioxidants, Protein, Ser/Thr, Phosphatases, Tocris Bioscience

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