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Tocris/Prostaglandin E<sub>2</sub>/2296/10/10 mg

Tocris/Prostaglandin E₂/2296/10/10 mg

价格: ¥1668.00 市场价: 2780.00

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货号: 2296/10

品牌: Tocris

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Description: Major endogenous prostanoid

Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP₁, EP₂, EP₃ and EP₄ receptors (K_d values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.

Compound Libraries

Prostaglandin E₂ is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	352.47
Formula	C₂₀H₃₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	363-24-6
PubChem ID	5280360
InChI Key	XEYBRNLFEZDVAW-ARSRFYASSA-N
Smiles	CCCCC[C@H](O)C=C[C@H]1[C@H](O)CC(=O)[C@@H]1CC=C/CCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.25	100
	ethanol	15.86	45

Preparing Stock Solutions

The following data is based on the product molecular weight 352.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.37 mL
5 mM	0.57 mL	2.84 mL	5.67 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Coleman et al (1994) Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol.Rev. 46 205 PMID: 7938166

Hata and Breyer (2004) Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharm.Ther. 103 147 PMID:

North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447 1007 PMID: 17581586

Keywords: Prostaglandin E2, supplier, endogenous, prostanoid, EP1, EP2, EP3, EP4, Receptors, prostaglandins, prostacyclins, eicosanoids, ProstaglandinE2, stem, cells, e2, Prostanoid, Receptors, Stem, Cell, Signaling, Stem, Cell, Proliferation, Prostanoid, Receptors, Tocris Bioscience

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