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Tocris/Moxonidine hydrochloride/2282/50/50 mg

价格: ¥7020.00 市场价: 11700.00

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货号: 2282/50

品牌: Tocris

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Description: I₁ receptor and α₂-adrenoceptor agonist (I₁ > α₂)

Chemical Name: 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Mixed I₁ imidazoline receptor and α₂-adrenergic agonist; displays 40-fold higher affinity for I₁ receptors versus α₂-adrenoceptors. Centrally acting antihypertensive agent.

Compound Libraries

Moxonidine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	278.14
Formula	C₉H₁₂ClN₅O.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	75536-04-8
PubChem ID	11231255
InChI Key	ZZPAWQYZQVUVHX-UHFFFAOYSA-N
Smiles	Cl.COC1=NC(C)=NC(Cl)=C1NC1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.81	100
	ethanol	27.81	100

Preparing Stock Solutions

The following data is based on the product molecular weight 278.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.6 mL	17.98 mL	35.95 mL
5 mM	0.72 mL	3.6 mL	7.19 mL
10 mM	0.36 mL	1.8 mL	3.6 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Schafer et al (2002) Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and α₂-adrenoceptors. J.Pharmacol.Exp.Ther. 303 1163 PMID: 12438540

El-Ayoubi et al (2004) Imidazoline receptors but not a2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J.Pharmacol.Exp.Ther. 310 446 PMID: 15075383

Chan et al (2005) Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience 132 991 PMID: 15857704

Keywords: Moxonidine hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, I1, receptors, Imidazoline, I1, Receptors, Adrenergic, Alpha-2, Receptors, I1, Receptors, Tocris Bioscience

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