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Tocris/Raloxifene hydrochloride/2280/50/50 mg

价格: ¥1068.00 市场价: 1780.00

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货号: 2280/50

品牌: Tocris

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Description: Selective estrogen receptor modulator (SERM)

Alternative Names: LY 139481, Keoxifene

Chemical Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC₅₀ of 1 nM.

Compound Libraries

Raloxifene hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	510.04
Formula	C₂₈H₂₇NO₄S.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	82640-04-8
PubChem ID	54900
InChI Key	BKXVVCILCIUCLG-UHFFFAOYSA-N
Smiles	Cl.OC1=CC=C(C=C1)C1=C(C(=O)C2=CC=C(OCCN3CCCCC3)C=C2)C2=CC=C(O)C=C2S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.5	50

Preparing Stock Solutions

The following data is based on the product molecular weight 510.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.96 mL	9.8 mL	19.61 mL
5 mM	0.39 mL	1.96 mL	3.92 mL
10 mM	0.2 mL	0.98 mL	1.96 mL
50 mM	0.04 mL	0.2 mL	0.39 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Fitzpatrick et al (1999) Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 140 3928 PMID: 10465261

Bryant (2001) Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator. Rev.Endocr.Metab.Disord. 2 129 PMID: 11704975

Hibner et al (2004) Effects of raloxifene hydrochloride on endometrial cancer cells in vitro. Gynecologic Oncol. 93 642 PMID:

Todorova (2011) Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 67 285 PMID: 20383709

Keywords: Raloxifene hydrochloride, supplier, Selective, estrogen, receptor, modulators, SERM, ER, Estrogen, Receptors, LY139481, amino, acid, transporter, 2, ASCT2, LY, 139481, Keoxifene, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience

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