Alternative Names: (±)-p-Octopamine, Epirenor, Norfen
Chemical Name:α-(Aminomethyl)-4-hydroxybenzenemethanol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor agonist. Stimulates lipolysis in mammalian adipocytes via activation of β3 receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β3 receptor activation but stimulates transport when oxidized by MAO. Also activates human α2A receptors, inhibiting subsequent cAMP production.
Technical Data
M. Wt
189.64
Formula
C8H11NO2.HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
CAS Number
770-05-8
PubChem ID
20592
InChI Key
PUMZXCBVHLCWQG-UHFFFAOYSA-N
Smiles
Cl.NCC(O)C1=CC=C(O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
water
18.96
100
Preparing Stock Solutions
The following data is based on the product molecular weight 189.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
5.27 mL
26.37 mL
52.73 mL
5 mM
1.05 mL
5.27 mL
10.55 mL
10 mM
0.53 mL
2.64 mL
5.27 mL
50 mM
0.11 mL
0.53 mL
1.05 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
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References
References are publications that support the products' biological activity.
Airriesset al (1997) Selective inhibition of adenylyl cyclase by octopamine via a human cloned α2A-adrenoceptor. Br.J.Pharmacol. 122 191 PMID: 9313925
Roeder
(1999) Octopamine in invertebrates. Prog.Neurobiol. 59 533 PMID: 10515667
Visentinet al (2001) Dual action of octopamine on glucose transport into adipocytes: inhibition via β3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J.Pharmacol.Exp.Ther. 299 96 PMID: 11561068
Carpeneet al (1999) Selective activation of β3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn-Schmied.Arch.Pharmacol. 359 310 PMID: