Description:Fluorescenttaxolderivative
ChemicalName:(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-ylesterN-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Afluorescenttaxolderivativethatbindstothetaxolmicrotubulebindingsitewithhighaffinity(Ka~107M-1).UsefulfordirectimagingofthemicrotubuleCytoskeleton.Excitationmaximum~495nm;emissionmaximum~520nm.
TechnicalData
| M.Wt | 1283.3 |
| Formula | C71H66N2O21 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 191930-58-2 |
| PubChemID | 16760423 |
| InChIKey | JMWJJMCMRRQCSY-ADONSEPTSA-N |
| Smiles | O=C2[C@@]3(C)C([C@@]4(OC(C)=O)[C@H](OC4)C[C@@H]3OC([C@H](C)NC(C7=CC=C(C8=C(C=C%10)C(OC9=C8C=CC(O)=C9)=CC%10=O)C(C(O)=O)=C7)=O)=O)[C@H](OC(C6=CC=CC=C6)=O)[C@@]1(O)[C@](C)(C)C([C@H]2OC(C)=O)=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(C%11=CC=CC=C%11)=O)=O)C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 128.33 | 100 |
| ethanol | 128.33 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1283.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 0.78mL | 3.9mL | 7.79mL |
| 5mM | 0.16mL | 0.78mL | 1.56mL |
| 10mM | 0.08mL | 0.39mL | 0.78mL |
| 50mM | 0.02mL | 0.08mL | 0.16mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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