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Tocris/STEARDA/2204/10/10 mg

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货号: 2204/10

品牌: Tocris

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Description: Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors

Alternative Names: N-Stearoyldopamine

Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]octadecanamide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB₁ receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC₅₀ > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca²⁺ (EC₅₀ lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC₅₀ = 16 nM).

Technical Data

M. Wt	419.64
Formula	C₂₆H₄₅NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	105955-10-0
PubChem ID	10025103
InChI Key	KOCSVLPLQCBIGW-UHFFFAOYSA-N
Smiles	O=C(NCCC1=CC=C(O)C(O)=C1)CCCCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	2.1	5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 419.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.91 mL	23.83 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099

De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251 PMID: 15289293

Keywords: STEARDA, supplier, Endogenous, lipid, active, vivo, Enhances, effects, endovanilloids, TRPV1, receptors, inhibitors, inhibits, 5-lipoxygenase, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, Lipoxygenase, Oxidase, Oxygenases, Oxidases, 5-LOX, N-Stearoyldopamine, TRPV, Lipoxygenase, TRPV, Tocris Bioscience

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