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Tocris/L-755,507/2197/10/10 mg
  • Tocris/L-755,507/2197/10/10 mg

Tocris/L-755,507/2197/10/10 mg

价格: ¥2100.00 市场价: 3500.00
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货号: 2197
品牌: Tocris
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    • Description:Verypotentandselectiveβ3partialagoNIST
      ChemicalName:4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      Potentβ3-adrenergicreceptorpartialagonist>1000-foldselectiveoverβ1-andβ2-adrenoceptors(EC50valuesare0.43,580and>10000nMforactivationofclonedhumanβ3-,β1-andβ2-adrenoceptorsrespectively).StimulateslipolysisinrhesusADIpocytesinvitro(EC50=3.9nM).EnhancesCRISPR-mediatedhomology-directedrepair(HDR)efficiency2-3-foldforlargefragmentsand~9-foldforpointmutations,inhumaninducedpluripotentstemcells(iPSCs).

      CompoundLibraries

      L-755,507isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

      TechnicalData

      M.Wt584.73
      FormulaC30H40N4O6S
      StorageStoreat+4°C
      Purity≥98%(HPLC)
      CASNumber159182-43-1
      PubChemID9829836
      InChIKeyNYYJKMXNVNFOFQ-MHZLTWQESA-N
      SmilesO=S(C1=CC=C(NC(NCCCCCC)=O)C=C1)(NC2=CC=C(CCNC[C@H](O)COC3=CC=C(O)C=C3)C=C2)=O

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO58.47100
      ethanol58.47100

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight584.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM1.71mL8.55mL17.1mL
      5mM0.34mL1.71mL3.42mL
      10mM0.17mL0.86mL1.71mL
      50mM0.03mL0.17mL0.34mL