Epstein-Barr virus induced gene 3 (EBI3) is a secretedglycoprotein belonging to the hematopoietin receptor familyrelated to the p40 subunit of interleukin 12 (IL-12). EBI3expression is induced in B-lymphocytes in response toEpstein-Barr virus infection. EBI3 forms heterodimers withp28 to form interleukin 27 (IL-27), and with p35 to forminterleukin 35 (IL-35). Both IL-27 and IL-35 haveanti-inflammatory and regulatory activity.
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