Epstein-Barr Virus Induced Gene-3 (EBI3), is a secretedglycoprotein belonging to the hematopoietin receptor family andis related to the p40 subunit of IL-12. EBI3 was identified byits induced expression in B-lymphocytes in response toEpstein-Barr virus infection. EBI3 forms heterodimers with p28 toform IL-27 and with p35 to form IL-35. Both IL-27 and IL-35 haveanti-inflammatory and regulatory activity. Recombinant human EBI3is a non-glycosylated protein, containing 209 amino acids, with amolecular weight of 23.3 kDa.
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