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Tocris/UBP 302/2079/50/50 mg

价格: ¥12540.00 市场价: 20900.00

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货号: 2079/50

品牌: Tocris

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Description: Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)

Chemical Name: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective GLU_K5 (GluR5)-subunit containing kainate receptor antagonist (apparent K_D = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GLU_K6- and GLU_K2-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.

Compound Libraries

UBP 302 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	333.3
Formula	C₁₅H₁₅N₃O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	745055-91-8
PubChem ID	6420161
InChI Key	UUIYULWYHDSXHL-NSHDSACASA-N
Smiles	O=C(C=CN(C[C@H](N)C(O)=O)C2=O)N2CC1=CC=CC=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	8.33	25
	DMSO	6.67	20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 333.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3 mL	15 mL	30 mL
5 mM	0.6 mL	3 mL	6 mL
10 mM	0.3 mL	1.5 mL	3 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

More et al (2004) Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 47 46 PMID: 15165833

Dolman et al (2005) Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J.Med.Chem. 48 7867 PMID: 16302825

Apland et al (2014) The Limitations of Diazepam as a Treatment for Nerve Agent-Induced Seizures and Neuropathology in Rats: Comparison with UBP302. J.Pharmacol.Exp.Ther. 351 359 PMID: 25157087

Keywords: UBP 302, supplier, Selective, potent, kainate, antagonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, UBP302, neurodegeneration, Kainate, Receptors, Kainate, Receptors, Tocris Bioscience

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