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Tocris/Mirtazapine/2018/10/10 mg

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货号: 2018/10

品牌: Tocris

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Description: Potent 5-HT₂ antagonist. Also 5-HT₃, H₁ and α₂-antagonist. Antidepressant

Alternative Names: Org 3770, 6-Azamianserin

Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Antidepressant agent; potent 5-HT₂, 5-HT₃ and histamine H₁ receptor antagonist and moderately potent α₂-adrenoceptor antagonist (pK_i values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenalin (NA) release in rat brain via inhibition of α₂-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pK_i values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.

Compound Libraries

Mirtazapine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	265.36
Formula	C₁₇H₁₉N₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	85650-52-8
PubChem ID	4205
InChI Key	RONZAEMNMFQXRA-UHFFFAOYSA-N
Smiles	CN1CCN2C(C1)C1=CC=CC=C1CC1=C2N=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	5.31	20
	ethanol	13.27	50

Preparing Stock Solutions

The following data is based on the product molecular weight 265.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.77 mL	18.84 mL	37.68 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
10 mM	0.38 mL	1.88 mL	3.77 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

de Boer et al (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 27 399 PMID: 3419539

Kooyman et al (1994) Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 33 501 PMID: 7984289

de Boer et al (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazepine, mianserin and idazoxan. J.Pharmacol.Exp.Ther. 277 852 PMID: 8627567

Keywords: Mirtazapine, supplier, Potent, 5-HT3, antagonists, 5-HT2, H1, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Antidepressant, Serotonin, Receptors, Non-Selective, Histamine, histaminergic, Org3770, Org, 3770, 6-Azamianserin, Non-selective, 5-HT2, 5-HT3, Receptors, Histamine, H1, Receptors, Adrenergic, Alpha-2, Receptors, Non-selective, 5-HT2, Tocris Bioscience

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