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Tocris/PSB 1115/2009/10/10 mg

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货号: 2009/10

品牌: Tocris

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Description: Selective human A_2B receptor antagonist; water-soluble

Chemical Name: 4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Highly selective, water-soluble, human A_2B adenosine receptor antagonist. K_i values are 53.4, > 10000 and > 10000 nM at human A_2B, A₁ and A₃ receptors respectively. Also selective versus rat A₁ and A_2A receptors (K_i values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo.

Compound Libraries

PSB 1115 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	350.35
Formula	C₁₄H₁₄N₄O₅S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	152529-79-8
PubChem ID	5311479
InChI Key	UYDRRQPGDSIMNU-UHFFFAOYSA-N
Smiles	O=C(NC2=C1NC(C3=CC=C(S(=O)(O)=O)C=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.84	100
	water	7.77	20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 350.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.27 mL	28.54 mL
5 mM	0.57 mL	2.85 mL	5.71 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Muller et al (1998) 8-(Sulfostyryl)xanthines: water-soluble A_2A-selective adenosine receptor antagonists. Bioorg.Med.Chem. 6 707 PMID: 9681137

Hayallah et al (2002) 1,8-Disubstituted xanthine derivatives: synthesis of potent A_2B-selective adenosine receptor antagonists. J.Med.Chem. 45 1500 PMID: 11906291

Abo-Salem et al (2004) Antinociceptive effects of novel A_2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther. 308 358 PMID: 14563788

Yan and Muller (2004) Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. J.Med.Chem. 47 1031 PMID: 14761205

Keywords: PSB 1115, supplier, Selective, human, A2B, receptors, antagonists, water-soluble, adenosines, PSB1115, Adenosine, A2B, Receptors, Adenosine, A2B, Receptors, Tocris Bioscience

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