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Tocris/Paxilline/2006/10/10 mg

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货号: 2006/10

品牌: Tocris

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Description: SERCA ATPase blocker. Also potent BK_Ca channel blocker

Chemical Name: (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent blocker of high-conductance Ca²⁺-activated K⁺ (BK_Ca, K_Ca1.1) channels. Binds to the α-subunit of BK_Ca (K_i = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BK_Ca channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca²⁺-ATPase (IC₅₀ = 5 - 50 μM).

Technical Data

M. Wt	435.56
Formula	C₂₇H₃₃NO₄
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	57186-25-1
PubChem ID	105008
InChI Key	ACNHBCIZLNNLRS-UBGQALKQSA-N
Smiles	[H][C@@]4([C@](C)3[C@]5(C)[C@@](C([C@]6([H])CC5)=CC([C@@H]([C@](O)(C)C)O6)=O)(O)CC4)CC2=C3NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.56	100
	ethanol	8.71	20

Preparing Stock Solutions

The following data is based on the product molecular weight 435.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.3 mL	11.48 mL	22.96 mL
5 mM	0.46 mL	2.3 mL	4.59 mL
10 mM	0.23 mL	1.15 mL	2.3 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Knaus et al (1994) Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33 5819 PMID: 7514038

Sanchez and McManus (1996) Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology 35 963 PMID: 8938726

Bilmen et al (2002) The mechanism of inhibition of the sarco/endoplasmic reticulum Ca²⁺ ATPase by paxilline. Arch.Biochem.Biophys. 406 55 PMID: 12234490

Keywords: Paxilline, supplier, Potent, blockers, BKCa, channels, SERCA, ATPases, Potassium, ca2+-activated, ca2+-dependent, Ca2+-ATPase, Signaling, Signalling, Calcium, Calcium-ATPase, Ion, Transporters, Pumps, Ca2+-Activated, Potassium, Channels, Ca2+-ATPase, Ca2+-ATPase, Tocris Bioscience

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