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Tocris/Isradipine/2004/50/50 mg

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货号: 2004/50

品牌: Tocris

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Description: Ca²⁺ channel blocker (L-type)

Alternative Names: PN 200-110

Chemical Name: 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective L-type voltage-gated Ca²⁺ channel blocker. EC₅₀ and pA₂ values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca²⁺-induced contractions of rabbit aorta respectively; EC₂₅ = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.

Compound Libraries

Isradipine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	371.39
Formula	C₁₉H₂₁N₃O₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	75695-93-1
PubChem ID	3784
InChI Key	HMJIYCCIJYRONP-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.57	50
	ethanol	7.43	20

Preparing Stock Solutions

The following data is based on the product molecular weight 371.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.93 mL
5 mM	0.54 mL	2.69 mL	5.39 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Hof et al (1984) PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. J.Cardiovasc.Pharmacol. 6 399 PMID: 6202964

Wada et al (1985) Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart. J.Cardiovasc.Pharmacol. 7 190 PMID: 2580142

Ruegg and Hof (1990) Pharmacology of the calcium antagonist isradipine. Drugs 40 3 PMID:

Keywords: Isradipine, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, PN200110, PN, 200-110, Voltage-gated, Calcium, Channels, Voltage-gated, Calcium, Channels, Tocris Bioscience

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