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Tocris/Linopirdine dihydrochloride/1999/50/50 mg

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货号: 1999/50

品牌: Tocris

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Description: K_V7 (KCNQ) channel blocker

Alternative Names: DuP 996

Chemical Name: 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Blocker of K_V7 (KCNQ) voltage-gated potassium channels; blocks K_V7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC₅₀ = 4 - 7 μM) and K_V7.1 (KCNQ1) homomeric channels (IC₅₀ = 8.9 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Compound Libraries

Linopirdine dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	464.39
Formula	C₂₆H₂₁N₃O.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	113168-57-3
PubChem ID	14209557
InChI Key	ZEVVHCGTTNRYOY-UHFFFAOYSA-N
Smiles	Cl.Cl.O=C1N(C2=CC=CC=C2C1(CC1=CC=NC=C1)CC1=CC=NC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.44	100
	ethanol	46.44	100
	water	46.44	100

Preparing Stock Solutions

The following data is based on the product molecular weight 464.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.77 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Schnee and Brown (1998) Selectivity of linopirdine (DuP 966), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J.Pharmacol.Exp.Ther. 286 709 PMID: 9694925

Wang et al (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282 1890 PMID: 9836639

Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724 PMID: 9580619

Keywords: Linopirdine dihydrochloride, supplier, KCNQ, channel, blockers, Potassium, KV, kv7, Channels, voltage-gated, voltage-dependent, K+, KCNQ2, KCNQ3, KCNQ1, DuP996, DuP, 996, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience

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